Thermo Fisher Scientific CRYAB Monoclonal Antibody (1A7.D5), PE

Applications and Tested Dilution

Product Specifications

Available Formats

• Unconjugated (MA5-27708)
• APC (MA5-45198)
• FITC (MA5-45199)
• PerCP (MA5-45200)
• Custom conjugation available upon request

Product Specific Information

• 0.5 µg/mL of MA5-45201 detects 50 ng purified alpha B crystallin by colorimetric immunoblot using Goat anti-mouse IgG:HRP as secondary antibody.
• Detects approximately 20 kDa (predicted molecular weight ≈ 21 kDa).
• No cross-reactivity with alpha A-crystallin, beta L-crystallin, beta H-crystallin, gamma-crystallin, HSP25, HSP27, or HSP47 proteins.

Target Information

Lens proteins are composed primarily of crystallins (≈95%), which maintain the proper refractive index of the lens. The mammalian lens includes three major classes: alpha, beta, and gamma crystallins.

• Alpha-crystallin: largest, composed of alpha-A and alpha-B subunits; accounts for 40% of total lens protein.
• Functions as a molecular chaperone, preventing aggregation and potential cataract formation.
• Phosphorylation may regulate structural and stress response functions.
• Alpha-B crystallin accumulation is associated with Alexander’s disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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