Thermo Fisher Scientific Cystatin 2 Monoclonal Antibody (C1)
Cystatin 2 단백질을 인식하는 Mouse monoclonal antibody (Clone C1). Western blot, IHC(P), ICC/IF에 사용 가능. Human 시료 반응성. Protein A/G 정제, PBS + 50% glycerol 보존. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–20 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C1 |
| Immunogen | Recombinant protein Cystatin 2 (amino acids 21–141 of target protein) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899058 |
Target Information
The cystatin superfamily is a well-established family of cysteine protease inhibitors.
Cystatins A and B (type 1) are mainly intracellular; cystatins C, D, E/M, F, G, S, SN, and SA are extracellular (type 2); and the kininogens are type 3 cystatins which are intravascular proteins.
All true cystatins inhibit cysteine peptidases of the papain family, such as cathepsins, and some also inhibit legumain family enzymes.
Cystatin SA, S, and SN are found primarily in saliva, while cystatin S and SN can also be expressed in tears, urine, and seminal fluid.
Cystatin C is expressed in brain, thymus, ovary, epididymis, and vas deferens.
Cystatin D protects against proteinases in the oral cavity, while cystatin E/M and F moderate the inhibition of cathepsin proteins.
The fetuins, part of the cystatin superfamily, are secretable proteins that influence osteogenesis, bone resorption, regulation of insulin and hepatocyte growth factor receptors, and the response to systemic inflammation.
High and low molecular weight kininogens inhibit thrombin- and plasmin-induced thrombocyte aggregation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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