Thermo Fisher Scientific Cyclophilin A Monoclonal Antibody (C1)
Cyclophilin A 단백질을 인식하는 Mouse monoclonal antibody (Clone C1). Western blot 및 IHC(P) 검증 완료. Protein A/G로 정제된 1 mg/mL 액상 시약으로, PBS 및 50% glycerol buffer에 보관. 인체 유래 단백질 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–30 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C1 |
| Immunogen | Recombinant protein Cyclophilin A (amino acids 2–165 of target protein) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899057 |
Target Information
Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents—cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs), and those that bind cyclosporin A are called cyclophilins (CyP).
Both CyP:CsA and FKBP:FK506 complexes inhibit calcineurin, a calcium and calmodulin-dependent protein phosphatase involved in T-cell activation, providing a mechanism for immunosuppression by CsA and FK506.
Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase), accelerating folding of some proteins by catalyzing proline-containing peptide bond rearrangements. Within the cyclophilin family, CyPA (also known as CyP-18) is the most abundant and ubiquitous form, found in all vertebrate tissues and present in T-cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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