Thermo Fisher Scientific P-Selectin (CD62P) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000
• Positive test controls: Mouse kidney, Rat brain
• Target localization: Membrane, Single-pass type I membrane protein

Product Specifications

Immunogen Sequence

FSFNSQCSFH CTDGYQVNGP SKLECLASGI WTNKPPQCLA AQCPPLKIPE RGNMTCLHSA KAFQHQSSCS FSCEEGFALV GPEVVQCTAS GVWTAPAPVC

Target Information

P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type I transmembrane glycoprotein involved in regulating cell rolling and adhesion. It is stored in the Weibel-Palade bodies of endothelial cells and α-granules of platelets, and rapidly translocates to the cell surface upon activation by thrombin, histamine, or other stimuli. P-selectin mediates interactions between activated endothelial cells or platelets and leukocytes, playing a key role in inflammatory and thrombotic processes. It is a calcium-dependent receptor binding sialylated Lewis antigens on neutrophils and monocytes, and is implicated in inflammation, atherogenesis, and thrombosis. Clinically, it helps distinguish heparin-induced thrombocytopenia with and without thrombosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.