Thermo Fisher Scientific Tyrosinase Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 20-340 of human Tyrosinase (NP_0003631) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Tyrosinase,uniProtId:P14679-1,ncbiNodeId:9606,antigenRange:20-340,antigenLength:529,antigenImageFileName:PA5-120174_Tyrosinase_P14679-1_Rabbit.svg,antigenImageFileNamePDP:PA5-120174_Tyrosinase_P14679-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.97 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2913746

Product Specific Information

Positive test controls include: Rat brain. The target is usually found in the following locations: Melanosome membrane, Single-pass type I membrane protein.

Immunogen sequence: PWSGDRSPCG QLSGRGSCQN ILLSNAPLGP QFPFTGVDDR ESWPSVFYNR TCQCSGNFMG FNCGNCKFGF WGPNCTERRL LVRRNIFDLS APEKDKFFAY LTLAKHTISS DYVIPIGTYG QMKNGSTPMF NDINIYDLFV WMHYYVSMDA LLGGSEIWRD IDFAHEAPAF LPWHRLFLLR WEQEIQKLTG DENFTIPYWD WRDAEKCDIC TDEYMGGQHP TNPNLLSPAS FFSSWQIVCS RLEEYNSHQS LCNGTPEGPL RRNPGNHDKS RTPRLPSSAD VEFCLSLTQY ESGSMDKAAN FSFRNTLEGF ASPLTGIADA S

Target Information

The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3` half of this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.