Thermo Fisher Scientific DR4 Polyclonal Antibody
DR4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, ICC/IF, ELISA 등 다양한 응용 가능. 고순도의 Affinity Chromatography 정제 제품으로 인체, 생쥐, 랫트 반응성. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 269–468 of human TNFRSF10A (NP_003835.3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.39 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2913747 |
Product Specific Information
Positive test controls include: K-562, SW480, MCF7, HeLa, DU145, Mouse lung, Rat lung.
The target is usually found in the following locations: Membrane, Single-pass type I membrane protein.
Immunogen sequence:
GGDPKCMDRV CFWRLGLLRG PGAEDNAHNE ILSNADSLST FVSEQQMESQ EPADLTGVTV QSPGEAQCLL GPAEAEGSQR RRLLVPANGA DPTETLMLFF DKFANIVPFD SWDQLMRQLD LTKNEIDVVR AGTAGPGDAL YAMLMKWVNK TGRNASIHTL LDALERMEER HAREKIQDLL VDSGKFIYLE DGTGSAVSLE
Target Information
TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1.
The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family.
DR4 mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a critical process in normal cellular differentiation and development of multicellular organisms.
Apoptosis is induced by coupling of certain cytokines (TNF family – TNF, Fas ligand) and their death domain-containing receptors (TNFR1, Fas receptor).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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