Thermo Fisher Scientific Human IRAK2 Synthetic Peptide

Thermo Fisher Scientific Human IRAK2 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 20 amino acids near the carboxy terminus of human IRAK2.
PEP-0062 can be used as a blocking peptide with polyclonal antibody PA5-19937.

Target Information

IRAK2 (interleukin-1 receptor-associated kinase-like 2) binds to the IL-1 type I receptor following IL-1 engagement and triggers intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
The pro-inflammatory cytokine IL-1 induces cellular responses through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP).
IRAK mediates activation of NF-kappa-B, a pivotal transcription factor for inflammatory and immune responses.
IRAK2, a novel member of the IRAK/Pelle family, recruits to the IL-1R complex after IL-1 binding and leads to NF-kappa-B activation.
IRAKs also associate with Toll-like receptors (TLR), and dominant negative mutants of IRAKs inhibit LPS-induced NF-kappa-B activation.
Members of the IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory responses to cytokine IL-1 and LPS.
IRAK2 is expressed in a variety of human tissues.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.