Thermo Fisher Scientific Human ARC Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 17 amino acids at the amino terminus of human ARC.
PEP-0059 can be used as a blocking peptide with polyclonal antibody PA5-19934.

Target Information

ARC (also known as NOL3 - Nucleolar protein 3) has two isoforms.

• Isoform 1 is involved in RNA splicing.
• Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death.

ARC inhibits extrinsic apoptotic pathways in two ways:

1. By interacting with FAS and FADD upon FAS activation, blocking death-inducing signaling complex (DISC) assembly.
2. By interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation.

ARC also inhibits intrinsic apoptotic pathways through interactions with BAX, resulting in BAX inactivation and prevention of mitochondrial dysfunction and release of pro-apoptotic factors.
Mutations affecting this gene can result in myoclonus, familial cortical.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.