Thermo Fisher Scientific Phospho-HPD (Thr382) Polyclonal Antibody
HPD 단백질의 Thr382 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot 검증 완료. 인간, 마우스, 랫트 반응성. 액상 형태, 1 mg/mL 농도, PBS/glycerol buffer에 보관. 연구용으로만 사용 가능.
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- PA5106228
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human HPD (Accession P32754), corresponding to amino acid residues around phosphorylated Thr382 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817626 |
Product Specific Information
This antibody detects endogenous levels of HPD only when phosphorylated at Thr382.
Target Information
The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity. A mitochondrial serine protease, Omi/HtrA2, is released upon induction of apoptosis and binds to IAP. Like Smac/DIABLO, the mature Omi protein contains a conserved IAP-binding motif (AVPS) at its N-terminus. Deregulated expression of Omi in the cytoplasm of mammalian cells induces apoptosis, indicating that Omi participates in the mitochondrial apoptotic pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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