Thermo Fisher Scientific Tau Monoclonal Antibody (S.125.0)
Tau 단백질을 인식하는 Mouse monoclonal antibody (Clone S.125.0). Western blot, IHC, ICC 등 다양한 응용 가능. Human, Mouse, Rat 반응성. 액상형, Unconjugated, -20°C 보관. 알츠하이머병 등 신경퇴행성 질환 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 2 publications |
| Immunohistochemistry (IHC) | – | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC-P) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | S.125.0 |
| Immunogen | Native bovine tau; epitope maps to the carboxy-terminus of the protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 646 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_11009623 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Tau is a neuronal microtubule-associated protein primarily located in axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules, while the N-terminus associates with neural plasma membrane components, functioning as a linker between cytoskeletal and membrane structures.
Tau localization determines axonal polarity within neurons. Short isoforms contribute to cytoskeletal plasticity, whereas longer isoforms aid stabilization. Hyper-phosphorylated Tau forms paired helical filaments (PHF), the main component of neurofibrillary tangles in Alzheimer’s disease (AD). This modification disrupts microtubule binding, leading to neuronal degeneration.
Tau phosphorylation is mediated by several kinases, including GSK-3β, PKA, cdk5, and casein kinase II. Hyper-phosphorylated Tau is implicated in Alzheimer’s disease, Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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