Thermo Fisher Scientific GSK3B Monoclonal Antibody (E.948.2)
GSK3B 단백질을 표적하는 Rabbit Monoclonal Antibody로, Western Blot, IHC, ICC, IP 등에 사용 가능. 인간, 마우스, 원숭이, 랫트 반응성. 고순도 Affinity chromatography로 정제된 액상 항체로 연구용에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 | - |
| Immunocytochemistry (ICC/IF) | - | View 2 publications |
| Immunoprecipitation (IP) | 1:50 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | E.948.2 |
| Immunogen | Synthetic peptide corresponding to the sequence of human GSK-3ß |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 13 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10986304 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
GSK3B is a proline-directed serine/threonine protein kinase involved in energy metabolism, neuronal cell development, and body pattern formation. It negatively regulates glucose homeostasis and participates in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways.
GSK3B is a critical component of the Wnt/beta-catenin signaling pathway, where its activity inhibits Wnt signaling by mediating beta-catenin degradation. It is also involved in Hedgehog, Notch, and insulin signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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