Thermo Fisher Scientific PARN Monoclonal Antibody (OTI1G7), TrueMAB

Applications

• Western Blot (WB): 1:2,000 dilution tested

Product Specifications

Target Information

The protein encoded by this gene is a 3′-exoribonuclease, with similarity to the RNase D family of 3′-exonucleases. It prefers poly(A) as the substrate and efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, and in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been identified.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.