Thermo Fisher Scientific PGR Monoclonal Antibody (OTI24A2), TrueMAB
프로게스테론 수용체(PGR)를 인식하는 마우스 단클론 항체로, Western blot에 최적화됨. 인간 시료에 반응하며 1:2,000 희석 권장. 고순도 친화 크로마토그래피 정제, PBS/BSA/glycerol 저장. 연구용 전용 제품.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI24A2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–298 of human PGR produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. It mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy.
PR exists as two major isoforms: a 94 kDa protein (Form A) and a 120 kDa protein (Form B) due to alternative translation initiation sites. PR-B is transcriptionally active and regulates genes involved in endometrial maintenance, pregnancy, and ovulation inhibition.
PR-A lacks 165 amino acids at the N-terminus, exposing an inhibitory domain that represses steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex with heat shock proteins and immunophilins. Upon progesterone binding, conformational changes enable dimerization and binding to progesterone response elements (PRE), activating transcription.
A null mutation in the PGR gene can result in reproductive abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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