Thermo Fisher Scientific PGR Monoclonal Antibody (OTI24A2), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Target Information

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. It mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy.
PR exists as two major isoforms: a 94 kDa protein (Form A) and a 120 kDa protein (Form B) due to alternative translation initiation sites. PR-B is transcriptionally active and regulates genes involved in endometrial maintenance, pregnancy, and ovulation inhibition.
PR-A lacks 165 amino acids at the N-terminus, exposing an inhibitory domain that represses steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex with heat shock proteins and immunophilins. Upon progesterone binding, conformational changes enable dimerization and binding to progesterone response elements (PRE), activating transcription.
A null mutation in the PGR gene can result in reproductive abnormalities.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.