Thermo Fisher Scientific PGR Monoclonal Antibody (OTI18B12), TrueMAB
Progesterone 수용체(PGR)에 특이적인 Mouse monoclonal antibody로 Western blot 및 IHC(Paraffin)에 사용 가능. 인간 시료에 반응하며 고순도 affinity chromatography로 정제됨. 액상 형태로 안정적이며 연구용으로 적합.
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Applications
- Western Blot (WB): 1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI18B12 |
| Immunogen | Human recombinant protein fragment (aa 1–298 of human PGR) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. It mediates the physiological effects of progesterone, crucial for reproductive processes such as pregnancy establishment and maintenance.
PR exists as two forms: 94 kDa (Form A) and 120 kDa (Form B), generated by alternative translation initiation. PR-B is transcriptionally active, regulating genes for endometrial maintenance, pregnancy, and ovulation inhibition.
PR-A lacks 165 amino acids at the N-terminus, exposing an inhibitory domain that represses transcriptional activity.
In its inactive state, PgR forms a multiprotein complex with heat shock proteins and immunophilins. Progesterone binding induces conformational change, receptor dimerization, and DNA binding to progesterone response elements (PRE), activating transcription.
A null mutation in the PGR gene results in reproductive abnormalities.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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