Thermo Fisher Scientific LAP (Latency Associated Peptide) Monoclonal Antibody (7F6)
인간 TGFβ1을 인식하는 마우스 단클론 항체로, WB, IHC, FACS, ELISA에 사용 가능. 단백질 G로 정제된 액상 포맷이며, 1 mg/mL 농도. 짧은 기간은 4°C, 장기 보관은 -20°C 권장. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7F6 |
| Immunogen | Purified recombinant fragment of human TGFβ1 (amino acids 62–195) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538657 |
Product Specific Information
MA5-17186 targets TGFβ1 in FACS, IHC, indirect ELISA, and WB applications, showing reactivity with human samples.
The immunogen is a purified recombinant fragment of human TGFβ1 (amino acids 62–195) expressed in E. coli.
MA5-17186 detects TGFβ1, which has a predicted molecular weight of approximately 44.3 kDa.
Target Information
TGF beta-1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues.
Transforming growth factor (TGF)-β is stored in the extracellular matrix as a latent complex with its prodomain.
Activation of TGF-β1 requires the binding of αV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-β binding proteins.
Latent forms are complexes of TGF-beta, an aminoterminal portion of the TGF-beta precursor (designated TGF-LAP, latency associated peptide), and a specific binding protein known as LTBP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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