Thermo Fisher Scientific STAT5 alpha Monoclonal Antibody (6D4)
Human STAT5A 단백질을 인식하는 Mouse IgG1 단일클론 항체로, WB, IHC, ICC, Flow Cytometry 등 다양한 응용에 적합. 1 mg/mL 농도의 액상 형태로 제공되며, Protein G 정제. 연구용으로만 사용 가능.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific STAT5 alpha Monoclonal Antibody (6D4)
Thermo Fisher Scientific STAT5 alpha Monoclonal Antibody (6D4)
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:50 | - |
| Flow Cytometry (Flow) | 1:200–1:400 | - |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6D4 |
| Immunogen | Purified recombinant fragment of human STAT5A (amino acids 583–794) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538654 |
Product Specific Information
MA5-17183 targets STAT5A in FACS, ICC, IHC, and WB applications and shows reactivity with human samples.
The immunogen is a purified recombinant fragment of human STAT5A (amino acids 583–794) expressed in E. coli.
MA5-17183 detects STAT5A, which has a predicted molecular weight of approximately 90.6 kDa.
Target Information
STAT5 alpha is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases and form homo- or heterodimers that translocate to the nucleus to act as transcription activators.
STAT5 alpha mediates responses to ligands such as IL2, IL3, IL7, GM-CSF, erythropoietin, thrombopoietin, and various growth hormones.
Activation of STAT5 alpha in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and essential for tumorigenesis.
In mouse, STAT5 alpha induces expression of BCL2L1/BCL-X(L), suggesting an anti-apoptotic function. STAT5 alpha and STAT5 beta share 96% sequence similarity and are co-expressed in most tissues, though differential mRNA accumulation occurs in muscle and mammary tissue.
STAT5 alpha plays critical roles in reproduction, lactation, immune function, and somatic growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.