Thermo Fisher Scientific MPP8 Polyclonal Antibody
Human MPP8 단백질을 인식하는 Rabbit polyclonal antibody로, Western blot 및 Immunoprecipitation에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 1 mg/mL 농도. H3K9me 결합 및 후성유전적 억제 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A region between residue 1 and 50 of human Mphase Phosphoprotein 8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Heterochromatin component that specifically recognizes and binds methylated Lys-9 of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416).
Mediates recruitment of the HUSH complex to H3K9me3 sites, which is required to maintain transcriptional silencing by promoting recruitment of SETDB1 and MORC2 (PubMed:26022416, PubMed:28581500).
Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to CpG sites (PubMed:20871592).
Mediates down-regulation of CDH1 expression and represses L1 retrotransposons with MORC2 and SETDB1 (PubMed:29211708).
The HUSH complex is also involved in silencing unintegrated retroviral DNA via recruitment by ZNF638 (PubMed:30487602).
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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