Thermo Fisher Scientific MPP8 Polyclonal Antibody
Rabbit polyclonal antibody targeting human MPP8 protein for WB and IP applications. Recognizes H3K9me3-related heterochromatin component involved in epigenetic repression. Supplied as liquid, 1 mg/mL concentration, stored at 4°C, shipped on wet ice.
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Thermo Fisher Scientific MPP8 Polyclonal Antibody
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A region between residue 1 and 50 of human Mphase Phosphoprotein 8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Heterochromatin component that specifically recognizes and binds methylated Lys-9 of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites, which is required to maintain transcriptional silencing by promoting recruitment of SETDB1 and MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites (PubMed:20871592). Mediates down-regulation of CDH1 expression and represses L1 retrotransposons in collaboration with MORC2 and SETDB1 (PubMed:29211708). The HUSH complex also silences unintegrated retroviral DNA by recruitment via ZNF638 (PubMed:30487602). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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