Thermo Fisher Scientific MPP8 Polyclonal Antibody
Rabbit에서 유래한 MPP8 폴리클로날 항체로, Western blot과 Immunoprecipitation에 적합합니다. 인간 M-phase Phosphoprotein 8의 200-250번 잔기 영역을 항원으로 사용하며, 액상 형태로 1 mg/mL 농도입니다. 후성유전학적 억제 복합체 연구에 활용됩니다.
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Thermo Fisher Scientific MPP8 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 200 and 250 of human M-phase Phosphoprotein 8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
Heterochromatin component that specifically recognizes and binds methylated Lys-9 of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416).
Mediates recruitment of the HUSH complex to H3K9me3 sites, maintaining transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase, and MORC2 (PubMed:26022416, PubMed:28581500).
Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites (PubMed:20871592).
Mediates down-regulation of CDH1 expression and represses L1 retrotransposons in collaboration with MORC2 and SETDB1 (PubMed:29211708).
The HUSH complex also silences unintegrated retroviral DNA by recruitment via ZNF638 (PubMed:30487602).
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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