Thermo Fisher Scientific CD262 (DR5) Monoclonal Antibody (DJR2-4 (7-8)), PE, eBioscience
인간 DR5(TRAIL-R2)를 인식하는 마우스 모노클론 항체로, PE 형광표지되어 있습니다. 유세포분석(Flow Cytometry)에 최적화되어 있으며, 5 µL(0.25 µg)/test로 사용 가능합니다. PBS 완충액에 0.2% BSA 및 0.09% sodium azide 포함, 4°C 암소 보관.
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2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD262 (DR5) Monoclonal Antibody (DJR2-4 (7-8)), PE, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | 5 µL (0.25 µg)/test | View 40 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DJR2-4 (7-8) |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10671016 |
Available Formats
Product Specific Information
Description:
The DJR2-4 monoclonal antibody reacts with human DR5, also known as TRAIL-R2, Apo2, TRICK2, and KILLER. DR5 binds to TRAIL, activates NF-kappaB, and induces TRAIL-mediated apoptosis. DR5 is expressed broadly by normal tissues as well as several tumor cells.
Applications Reported:
The DJR2-4 (a.k.a. 7-8) antibody has been reported for use in flow cytometric analysis.
Applications Tested:
This antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells.
Recommended use: 5 µL (0.25 µg) per test.
A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL.
Cell number should be determined empirically (10⁵–10⁸ cells/test).
Fluorescence Characteristics:
Excitation: 488–561 nm
Emission: 578 nm
Laser compatibility: Blue, Green, Yellow-Green lasers
Filtration:
0.2 µm post-manufacturing filtered.
Target Information
DR5 (Apo2, TRAIL-R2, TRICK2, KILLER):
A death domain-containing receptor for TRAIL, mediating TRAIL-induced apoptosis.
Member of the TNF-receptor superfamily with intracellular death domain.
Activated by TNFSF10/TRAIL/APO-2L and transduces apoptosis signals.
FADD adaptor protein is required for DR5-mediated apoptosis.
Two transcript variants and one non-coding transcript identified.
Overexpression induces apoptosis and activates NF-kappa-B.
Highly expressed in lymphocytes and spleen.
Associated diseases: squamous cell carcinoma, diffuse infiltrative lymphocytosis syndrome.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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