Thermo Fisher Scientific CPEB1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

PA1-1100 detects recombinant mouse and rat CPEB (cytoplasmic polyadenylation element binding protein).
It has been successfully used in Western blot, ICC/IF, and IHC-P procedures.
By Western blot, this antibody detects approximately 62 kDa protein representing recombinant mouse CPEB.
The immunogen is a synthetic peptide corresponding to residues C H(545) S M E G L R H H S P L M R N Q K N(562) of human CPEB, which is completely conserved in mouse.
The immunizing peptide (Cat. # PEP-171) is available for use in neutralization and control experiments.

Target Information

This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis.
Leukotrienes are arachidonic acid metabolites implicated in various inflammatory responses such as asthma, arthritis, and psoriasis.
This protein localizes to the nuclear membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the nuclear membrane and inhibit its activation.
Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.