Thermo Fisher Scientific CLAC-P Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 2–5 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 5–10 µg/mL

Product Specifications

Product Specific Information

PA1-10881 detects CLAC-P in human and mouse samples.
It has been successfully used in Western blot and immunohistochemistry (paraffin embedded sections) procedures.
A band of approximately 70 kDa is detected by Western blot in HEK293 cell lysate.
The immunogen is a synthetic peptide corresponding to residues 430–445 of the NC3 region of human and mouse CLAC-P.

Target Information

Alzheimer’s disease (AD) is characterized by deposition of beta-amyloid as senile plaques and cerebral amyloid angiopathy.
The principal component of AD amyloid is the amyloid beta peptide (Aβ).
Although production and deposition of Aβ appear closely related to the pathogenesis of AD, current evidence suggests that Aβ alone is not sufficient to cause neuronal death and symptoms of dementia.
A component of senile plaque (SP), CLAC (collagen-like Alzheimer amyloid plaque component) and its precursor CLAC-P are deposited with extracellular beta-amyloid and have been recently implicated in cell toxicity of beta-amyloid in AD brains.
CLAC-P is a unique, membrane-bound collagen-like structure containing three Gly-X-Y repeat motifs and may define a novel class of neuronal collagens.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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