Thermo Fisher Scientific Androgen Receptor (Marker of Androgen Dependence) Monoclonal Antibody (AR441, DHTR/882)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Does not react with Mouse.

Target Information

The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors.
It has three major functional domains:

1. N-terminal domain
2. DNA-binding domain
3. Androgen-binding domain

AR is a ligand-activated transcription factor that binds testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, it dissociates from accessory proteins, translocates into the nucleus, dimerizes, and activates transcription of androgen-responsive genes.

The AR signaling pathway is crucial for development and function of male reproductive organs (prostate, epididymis) and also affects nonreproductive tissues such as muscle, hair follicles, and brain.
AR is a phosphoprotein that regulates MAP kinase activity; inhibition of the MEK1/2 pathway alters AR phosphorylation.
Abnormal AR signaling is associated with prostate cancer, Kennedy’s disease, male infertility, and complete androgen insensitivity syndrome (CAIS).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.