Thermo Fisher Scientific Androgen Receptor (Marker of Androgen Dependence) Monoclonal Antibody (AR441, DHTR/882)
사람 유래 안드로겐 수용체(AR)를 인식하는 단클론 항체로, IHC(P) 및 IHC(PFA) 분석에 적합합니다. AR 신호전달 연구 및 남성 생식기 관련 질환 연구에 활용됩니다. 단백질 A/G 정제, 1 mg/mL 농도, 무보존제 PBS 용액 형태로 제공됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AR441, DHTR/882 |
| Immunogen | Synthetic peptide corresponding to aa 302–318 of human AR (AR441); recombinant human DHTR protein (DHTR/882) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Mouse.
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors.
It has three major functional domains:
- N-terminal domain
- DNA-binding domain
- Androgen-binding domain
AR is a ligand-activated transcription factor that binds testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, it dissociates from accessory proteins, translocates into the nucleus, dimerizes, and activates transcription of androgen-responsive genes.
The AR signaling pathway is crucial for development and function of male reproductive organs (prostate, epididymis) and also affects nonreproductive tissues such as muscle, hair follicles, and brain.
AR is a phosphoprotein that regulates MAP kinase activity; inhibition of the MEK1/2 pathway alters AR phosphorylation.
Abnormal AR signaling is associated with prostate cancer, Kennedy’s disease, male infertility, and complete androgen insensitivity syndrome (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송/결제/교환/반품 안내
배송 정보
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교환 및 반품 접수
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교환 및 반품 신청
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