Thermo Fisher Scientific Androgen Receptor (Marker of Androgen Dependence) Monoclonal Antibody (DHTR/882)
인간 안드로겐 수용체(AR)를 표지하는 단클론 항체로 다양한 면역염색 및 유세포분석에 사용 가능. DHTR/882 클론, 마우스 IgG1 아이소타입. 단백질 A/G로 정제된 액상 형태, 1 mg/mL 농도. 연구용으로만 사용.
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- 367-MSM2-P1ABX
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| Not applicable (N/A) | Assay-dependent |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DHTR/882 |
| Immunogen | Human DHTR recombinant protein fragment (aa151–350) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Mouse.
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. It is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon hormone binding, the receptor translocates to the nucleus, dimerizes, and activates transcription of androgen-responsive genes.
AR signaling is essential for development and function of male reproductive organs (prostate, epididymis) and also plays roles in muscle, hair follicles, and brain. It regulates MAP kinase activity, and MEK1/2 pathway inhibition correlates with AR phosphorylation changes. Abnormalities in AR signaling are associated with diseases such as prostate cancer, Kennedy’s disease, and male infertility. Mutations in this gene can cause complete androgen insensitivity (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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