Thermo Fisher Scientific Androgen Receptor (Marker of Androgen Dependence) Recombinant Rabbit Monoclonal Antibody (DHTR/8698R)
안드로겐 수용체(AR)를 검출하는 재조합 토끼 모노클로날 항체로, 인간 시료에 반응합니다. IHC(P) 및 IHC(PFA) 응용에 적합하며, CHO 세포에서 발현된 IgG 항체입니다. 단백질 A/G로 정제된 액상 형태로 제공되며, 연구용으로만 사용됩니다.
- 카탈로그번호
- 367-RBM13-P1ABX
- 판매단위
- pk
카탈로그
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | DHTR/8698R |
| Immunogen | Synthetic peptide corresponding to residues (within aa 1–100) of human Androgen Receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. It is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, the receptor translocates into the nucleus, dimerizes, and activates transcription of androgen-responsive genes.
AR signaling is essential for the development and function of male reproductive organs (prostate, epididymis) and also affects nonreproductive tissues such as muscle, hair follicles, and brain. It is a phosphoprotein that regulates MAP kinase pathways, and its dysfunction is associated with diseases such as prostate cancer, Kennedy’s disease, and male infertility. Mutations can cause complete androgen insensitivity (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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