Thermo Fisher Scientific CD80 Monoclonal Antibody (MEM-233), FITC
인간 CD80(B7-1)을 인식하는 마우스 단클론 항체로 FITC 형광 표지. Flow Cytometry에 최적화되어 있으며, PBS 기반 완충액에 보관. 항원 제시 세포의 CD80 발현 분석에 적합. 4°C 암소 보관, 동결 금지.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 20 µL/100 µL whole blood
- Publications: View 3 publications
Miscellaneous PubMed (Misc)
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-233 |
| Immunogen | Extracellular domain of human CD80 fused to human IgG1 (Fc) |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1073444 |
Additional Formats
- Unconjugated
- Alexa Fluor 700
- APC
- PE
- PerCP
- Custom conjugation available upon request
Product Specific Information
This antibody reacts with an extracellular epitope of CD80 (B7-1), a 60 kDa single-chain type I glycoprotein of the immunoglobulin superfamily, expressed on professional antigen-presenting cells such as dendritic cells, macrophages, and activated B lymphocytes.
Target Information
CD80 (B7-1) and CD86 (B7-2) are ligands of the T-cell costimulatory molecule CD28 and the inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T-cell activation. CD80 is rapidly induced on the surface of in vitro activated B cells, EBV-transformed B cell lines, Burkitt’s lymphoma cells, freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes via binding to CD28 and CTLA4 ligands.
Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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