Thermo Fisher Scientific FAK Recombinant Rabbit Monoclonal Antibody (SR46-04)

Thermo Fisher Scientific FAK Recombinant Rabbit Monoclonal Antibody (SR46-04)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This product is predicted to work in Immunoprecipitation.

Target Information

Focal Adhesion Kinase (FAK) is a 125 kDa non-receptor protein tyrosine kinase that serves as a substrate for Src and is a key component of integrin signaling.
FAK plays a crucial role in:

• Cell spreading, differentiation, migration, and cell death
• Regulation of the G1–S phase transition in the cell cycle

FAK has:

• A central catalytic domain
• A C-terminal tail that localizes to focal adhesions, sites where cells attach to the extracellular matrix via integrin receptors

Increased FAK tyrosine phosphorylation occurs upon integrin engagement with fibronectin.
Adhesion of murine NIH3T3 fibroblasts to fibronectin promotes association of Grb2 and c-Src PTK with FAK, resulting in activation of ERK2 MAP kinase.
In v-Src-transformed NIH3T3, the association of v-Src, Grb2, and Sos with FAK is independent of cell adhesion.
Grb2 SH2 domain binds directly to tyrosine-phosphorylated FAK at Tyr925.
Several transcript variants encoding different isoforms have been identified for the FAK gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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