Thermo Fisher Scientific PSD-95 Recombinant Rabbit Monoclonal Antibody (SR38-09)
PSD-95 단백질을 표적하는 재조합 토끼 단클론 항체로, WB, IHC, ICC/IF 등 다양한 응용에 적합합니다. HEK293 발현 시스템에서 생산되며 Protein A로 정제되었습니다. 인간, 마우스, 랫트 반응성을 가지며, 신경 시냅스 단백질 연구에 유용합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SR38-09 |
| Immunogen | Synthetic peptide within human PSD95 aa 1–40 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 0.05% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2898846 |
Product Specific Information
This product is predicted to work in Immunoprecipitation.
Target Information
Post Synaptic Density 95 kDa (PSD-95), also known as synapse associated protein 90 kDa (SAP90), is a membrane-associated protein found in the postsynaptic density of forebrain neurons and certain presynaptic structures in the cerebellum. PSD-95 contains three PDZ domains, an SH3 domain, and a Guanylate Kinase (GuK) domain.
It participates in clustering of NMDA receptors and Shaker-type potassium channels at the synaptic membrane in CNS neurons.
Interactions occur via the C-terminal T/SXV motif shared among NMDA receptors, potassium channels, and other neuronal proteins.
PSD-95 also interacts with neuronal nitric oxide synthase (nNOS) through PDZ-PDZ domain interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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