Thermo Fisher Scientific Bcl-2 Recombinant Rabbit Monoclonal Antibody (SZ10-03)
Thermo Fisher Scientific의 Bcl-2 Recombinant Rabbit Monoclonal Antibody (SZ10-03)는 인간 BCL-2 단백질을 인식하는 고특이성 항체로, WB, IHC, ICC, Flow Cytometry 등에 적합합니다. HEK293 발현 시스템 기반으로 제조되었으며, 단백질 A로 정제된 고순도 항체입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:4000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SZ10-03 |
| Immunogen | Synthetic peptide within human Bcl-2 aa 40–90 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 0.05% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2898850 |
Product Specific Information
This product is predicted to work in Immunoprecipitation.
Target Information
BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. Members of the BCL-2 family dimerize to modulate apoptosis. Bag1 forms a heterodimer with BCL-2, enhancing its anti-apoptotic effect. Bax and Bak are critical for cytochrome c release from mitochondria, initiating apoptosis. Overexpression or translocation of BCL-2 is associated with follicular lymphoma and other cancers such as B-cell lymphoma and prostate cancer. Two transcript variants of BCL-2 differ at the C-terminal end due to alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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