Thermo Fisher Scientific GPR17 Polyclonal Antibody
GPR17 단백질을 인식하는 Goat Polyclonal 항체로, Human 및 Mouse 시료에 반응합니다. Western blot과 Immunocytochemistry에 적합하며, 고순도의 액상 형태로 제공됩니다. 신경계의 희소돌기아교세포 분화 연구에 유용합니다.
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- PA519210
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2–3 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (EGKTNESSLSAKSE) corresponding to the C-terminus amino acids of GPR17 (aa 353–366) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_10977995 |
Product Specific Information
- This antibody is predicted to react with bovine based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:4,000.
Target Information
The G-protein-coupled receptor (GPCR) superfamily includes approximately 600–1,000 members and represents the largest known class of molecular targets with therapeutic potential.
GPR17 is an orphan G protein-coupled receptor involved in the orchestration of oligodendrocyte differentiation and myelination in the central nervous system.
It is expressed in brain, kidney, heart, and umbilical vein endothelial cells.
GPR17 has dual specificity for uracil nucleotides and cysteinyl leukotrienes and signals through G(i) and inhibition of adenylyl cyclase.
It may mediate brain damage by nucleotides and cysteinyl leukotrienes following ischemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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