Thermo Fisher Scientific HIV-1 gp120 (PNDmn) Monoclonal Antibody (ANT-151)

Applications

Tested Dilution

Publications

ELISA (ELISA)

1-5 µg/mL

-

Product Specifications

Species Reactivity

Virus

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

ANT-151

Immunogen

Recombinant gp120 (MN strain), a CCR5 and X4 tropic strain.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5-1.0 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute in 1 mL distilled water. Mix gently and wash the sides of the vial. Wait 1 minute before use.

Target Information

Human immunodeficiency virus type 1 (HIV-1) entry into target cells is directed by the envelope (Env) glycoproteins, which are present on the surface of HIV-1 virion or infected cells in the form of trimers consisting of gp120/gp41 complexes. The surface subunit, gp120, initiates the entry process by interacting sequentially with the CD4 receptor and a co-receptor CCR5 or CXCR4, thereby inducing a conformational change that allows the transmembrane (TM) gp41 subunit to mediate fusion between viral and target cell membranes. Cleavage of Env into its gp120 and gp41 components is necessary for activation of its fusogenic activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.