Thermo Fisher Scientific Factor XII Heavy chain Monoclonal Antibody (B7C9)

Applications

Western Blot (WB)

• Tested Dilution: Assay-dependent

ELISA

• Tested Dilution: Assay-dependent

Miscellaneous (PubMed)

• View 1 publication

Product Specifications

Product Specific Information

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Hemostasis following tissue injury involves the deployment of essential plasma procoagulants which are involved in a blood coagulation cascade leading to the formation of insoluble fibrin clots and the promotion of platelet aggregation.
Factor XII (FXII), a blood coagulation factor, is a serum glycoprotein that participates in fibrinolysis, as well as the generation of bradykinin and angiotensin.
An enzyme of the serine protease class, it activates both Factor XI and prekallikrein in the coagulation cascade.
Factor XII deficiency, a rare hereditary disorder slightly more prevalent among Asians, does not cause excessive hemorrhaging since other coagulation factors compensate for it.
However, Factor XII deficiency has been reported as a risk factor for arterial and venous thromboembolism.
The gene for human Factor XII maps to the very end of the long arm of the fifth chromosome (5q33-qter).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.