Thermo Fisher Scientific CD11b/c Monoclonal Antibody (OX-42)
Thermo Fisher Scientific의 CD11b/c Monoclonal Antibody (OX-42)는 rat 시료에서 CD11b/c 검출에 사용되는 mouse IgG2a 항체입니다. WB, IHC, ICC, Flow Cytometry 등 다양한 어플리케이션에 적합하며, macrophage 및 microglia 마커로 활용됩니다. 연구용 전용 제품입니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD11b/c Monoclonal Antibody (OX-42)
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | - |
| Immunohistochemistry (IHC) | Assay-dependent | 1 publication |
| Immunohistochemistry - Free Floating (IHC (Free)) | - | 1 publication |
| Immunocytochemistry (ICC/IF) | - | 1 publication |
| Flow Cytometry (Flow) | 1:25–1:200 (10 µL for 10^6 cells in 100 µL) | 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | 1 publication |
| Miscellaneous PubMed (Misc) | - | 1 publication |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Rat |
| Published Species | Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OX-42 |
| Immunogen | Rat macrophages |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | IgG fraction |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_558034 |
Additional Formats:
Product Specific Information
MA1-21591 detects CD11b/c in rat samples.
Target Information
Integrins are heterodimeric integral membrane proteins composed of an alpha and a beta chain.
CD11b is involved in adhesive interactions of monocytes, macrophages, and granulocytes, and mediates uptake of complement-coated particles. It is identical to CR3, the receptor for the iC3b fragment of complement component 3.
CD11b also serves as a receptor for fibrinogen, factor X, and ICAM1, recognizing P1 and P2 peptides of the fibrinogen gamma chain.
The Mac-1 CD11b antigen is found on macrophages, granulocytes, NK cells, and monocytes, expressed on 8% of spleen cells, 44% of bone marrow cells, and <1% of thymocytes. It is commonly used as a microglial marker in nervous tissue.
CD11c encodes the integrin alpha X chain, which forms with beta 2 (ITGB2) to create leukocyte-specific integrin CR4 (iC3b receptor 4). The αXβ2 complex overlaps with αMβ2 integrin in neutrophil and monocyte adhesion to stimulated endothelium and phagocytosis of complement-coated particles.
Mutations affecting the CD11b/c gene can lead to systemic lupus erythematosus 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.