Thermo Fisher Scientific ACBD3 Monoclonal Antibody (OTI1G2)
ACBD3 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, Western blot, IHC, Flow cytometry에 적합합니다. 다양한 종(인간, 마우스, 개, 원숭이, 랫드)에 반응하며, 액상 형태로 -20°C에서 보관 가능합니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1G2 |
| Immunogen | Full length human recombinant protein of ACBD3 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2722803 |
Target Information
GOLPH1 (also known as GCP60) was initially identified as a Golgi protein that interacts with the integral membrane protein giantin and is involved in maintaining Golgi structure. It also interacts with other Golgi proteins such as Golgin-160, which can be cleaved by caspases-2, -3, and -7, leading to nuclear localization of Golgin-160. The interaction between GOLPH1 and cleaved Golgin-160 fragments is stronger than with intact Golgin-160, regulated by the oxidation state of Cys-463 within GOLPH1. This suggests that nuclear localization of caspase-cleaved Golgin-160 fragments is a coordinated event. GOLPH1 also interacts with Numb, a cytosolic signaling protein involved in asymmetric cell division of neural progenitor cells, indicating that Golgi fragmentation and reconstitution during the cell cycle may regulate Numb signaling and couple cell fate with cell cycle progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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