Thermo Fisher Scientific DOK7 Monoclonal Antibody (OTI1A9)
DOK7 단백질을 인식하는 Mouse monoclonal antibody로 Western blot, IHC, ICC/IF, Flow Cytometry에 적합합니다. 인간 및 생쥐 시료 반응성이 있으며, PBS 기반 buffer에 보관됩니다. 신경근 시냅스 형성 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A9 |
| Immunogen | Full length human recombinant protein of DOK7 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723088 |
Target Information
The DOK7 protein is essential for neuromuscular synaptogenesis. It functions in aneural activation of muscle-specific receptor kinase (MuSK), which is required for postsynaptic differentiation and clustering of acetylcholine receptors in myotubes. DOK7 can induce autophosphorylation of MuSK. Mutations in this gene cause familial limb-girdle myasthenia autosomal recessive (congenital myasthenic syndrome type 1B). Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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