Thermo Fisher Scientific Cytokeratin 8 Monoclonal Antibody (C-43)
Cytokeratin 8 단백질을 인식하는 C-43 클론의 Mouse Monoclonal 항체로, Western blot, IHC, ICC, Flow cytometry 등에 사용 가능. Human 등 다양한 종에 반응하며, Protein A로 정제된 1 mg/mL 액상 형태. 4°C 보관, 동결 금지.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
| Flow Cytometry (Flow) | 0.5–4 µg/mL | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Sheep, Pig, Rabbit |
| Published Species | Goat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C-43 |
| Immunogen | Cytoskeleton preparation from HeLa human cervix carcinoma cell line |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1075193 |
Product Specific Information
This antibody reacts with cytokeratin 8 (52.5 kDa intracellular antigen). Cytokeratins are members of the intermediate filament subfamily represented in epithelial tissues.
This antibody does not cross-react with hamster, mouse, Xenopus, rat, or chicken.
Target Information
Cytokeratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells.
Cytokeratin 8 typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation.
Mutations in this gene cause cryptogenic cirrhosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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