Thermo Fisher Scientific Cytokeratin 18 Monoclonal Antibody (C-04)
Cytokeratin 18 단백질을 인식하는 Mouse monoclonal antibody (Clone C-04). Western blot, IHC, ICC, Flow cytometry, ELISA 등에 사용 가능. Human, Mouse, Rat 반응성. Protein A 정제, PBS buffer, 4°C 보관.
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- MA119039
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL | |
| Immunocytochemistry (ICC/IF) | Assay-dependent | |
| Flow Cytometry (Flow) | 1–4 µg/mL | |
| ELISA | Assay-dependent | |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mammal, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C-04 |
| Immunogen | Cytoskeleton preparation of epidermal carcinoma cell line A431 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1075170 |
Additional Conjugate Formats
Product Specific Information
This antibody reacts with cytokeratin 18 (45 kDa intracellular antigen), a member of the intermediate filament subfamily represented in epithelial tissues.
Western blot should be performed under non-reducing conditions.
Target Information
Cytokeratin 18 (Keratin 18, KRT18, type I cytoskeletal 18) belongs to the type A (acidic) subfamily of low molecular weight keratins and exists in combination with cytokeratin 8.
It is expressed in epithelial tissues from the gastrointestinal, respiratory, and urogenital tracts, as well as endocrine and exocrine tissues and mesothelial cells.
Cytokeratin 18 is primarily found in non-squamous epithelia and is present in most adenocarcinomas and ductal carcinomas, but not in squamous cell carcinomas.
Hepatocellular carcinomas express only cytokeratins 8 and 18.
Mutations in the cytokeratin 18 gene have been linked to cryptogenic cirrhosis.
Cytokeratin subtype expression patterns aid in distinguishing different epithelial malignancies.
Cytokeratin antibodies are valuable tools for tumor differential diagnosis using immunohistochemistry, cytopathology, and flow cytometry.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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