Thermo Fisher Scientific IL-31 Monoclonal Antibody (8-C3)
인간 IL-31을 인식하는 Mouse IgG3 단일클론 항체로 Western blot, IHC, ICC/IF에 사용 가능. 비결합형 액상 형태로 2 mg/mL 농도, PBS/glycerol/BSA buffer에 보관. 연구용으로 IL-31 관련 신호전달 및 면역반응 분석에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG3 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8-C3 |
| Immunogen | Recombinant protein within Human IL31 (aa 1–164) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2848818 |
Product Specific Information
Positive Control: Recombinant protein lysate, A431, LOVO, MCF-7, human tonsil tissue, human spleen tissue.
Target Information
Interleukin-31 (IL-31) is a T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells.
IL-31 activity is mediated through oligomerization of a receptor complex containing IL-31 receptor A and oncostatin M receptor, activating JAK/STAT and AKT signaling pathways.
IL-31 receptor A and oncostatin M receptor RNA levels are induced in activated monocytes and constitutively expressed in epithelial cells.
Overexpression of IL-31 in transgenic mice results in pruritis, alopecia, and skin lesions, and in humans may contribute to atopic dermatitis, suggesting IL-31 as a potential target for antipruritic drug development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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