Thermo Fisher Scientific RARA Monoclonal Antibody (OTI7B9), TrueMAB
RARA 단백질을 인식하는 Mouse monoclonal antibody (clone OTI7B9). Western blot에 최적화되어 있으며, Human 시료에 반응합니다. Lyophilized 형태로 제공되며, PBS buffer에 trehalose가 포함되어 안정성이 높습니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7B9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 52–299 of human RARA produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, it is recommended to perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
RARA (Retinoic Acid Receptor Alpha) is a receptor for retinoic acid. It forms heterodimers with RXR to bind retinoic acid response elements (RARE) and regulate gene expression in response to ligands such as all-trans or 9-cis retinoic acid.
In the absence of ligand, RXR-RAR heterodimers associate with corepressors leading to transcriptional suppression. Upon ligand binding, corepressors dissociate and coactivators are recruited, resulting in transcriptional activation.
RARA plays a critical role in germ cell development during spermatogenesis, skeletal growth, and matrix homeostasis, and mediates retinoic acid-induced granulopoiesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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