Thermo Fisher Scientific RARA Monoclonal Antibody (OTI1C6), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

• Reconstitute with 100 µL distilled water to obtain ~1 mg/mL antibody concentration.
• For conjugation experiments, perform additional desalting (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

RARA (Retinoic Acid Receptor Alpha) is a receptor for retinoic acid. It forms heterodimers with RXR and binds to retinoic acid response elements (RARE) to regulate gene expression.
In the absence of ligand, RXR-RAR heterodimers recruit corepressors leading to transcriptional suppression. Upon ligand binding, coactivators replace corepressors, activating transcription.
RARA is essential for retinoic acid-induced germ cell development during spermatogenesis and contributes to skeletal growth and matrix homeostasis. It mediates retinoic acid-induced granulopoiesis and regulates gene expression in a ligand-dependent manner via chromatin complexes containing KMT2E/MLL5.

For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.