Thermo Fisher Scientific RARA Monoclonal Antibody (OTI1C6), TrueMAB
인간 RARA 단백질(aa 52-299)을 인식하는 Mouse IgG1 단클론 항체로, Western blot에 적합합니다. 동결건조 형태로 제공되며 PBS/trehalose 버퍼에 재구성 후 사용합니다. 연구용으로만 사용 가능하며, retinoic acid 관련 유전자 발현 연구에 활용됩니다.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1C6 |
| Immunogen | Human recombinant protein fragment (aa 52–299 of RARA) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute with 100 µL distilled water to obtain ~1 mg/mL antibody concentration.
- For conjugation experiments, perform additional desalting (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
RARA (Retinoic Acid Receptor Alpha) is a receptor for retinoic acid. It forms heterodimers with RXR and binds to retinoic acid response elements (RARE) to regulate gene expression.
In the absence of ligand, RXR-RAR heterodimers recruit corepressors leading to transcriptional suppression. Upon ligand binding, coactivators replace corepressors, activating transcription.
RARA is essential for retinoic acid-induced germ cell development during spermatogenesis and contributes to skeletal growth and matrix homeostasis. It mediates retinoic acid-induced granulopoiesis and regulates gene expression in a ligand-dependent manner via chromatin complexes containing KMT2E/MLL5.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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