Thermo Fisher Scientific IL-10 Monoclonal Antibody (JES3-9D7), PE, eBioscience
인간 IL-10을 인식하는 JES3-9D7 클론 단일클론 항체로, PE 형광으로 표지되어 있습니다. 유세포 분석(Flow Cytometry)에 최적화되어 있으며, 0.25 µg/test로 사용 가능합니다. 친화 크로마토그래피로 정제되었고, 4°C 암소 보관이 권장됩니다.
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2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IL-10 Monoclonal Antibody (JES3-9D7), PE, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | 0.25 µg/test | View 22 publications |
| ELISA (ELISA) | – | View 1 publication |
| Functional Assay | – | View 1 publication |
| Miscellaneous PubMed | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Fungi, Human, Mouse |
| Host / Isotype | Rat / IgG1, kappa |
| Recommended Isotype Control | Rat IgG1 kappa Isotype Control (eBRG1), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | JES3-9D7 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_466178 |
Available Formats
- Unconjugated
- Alexa Fluor 488
- Brilliant UV 395
- Brilliant UV 737
- Brilliant Violet 421
- Brilliant Violet 480
- Brilliant Violet 711
- eFluor 450
- eFluor 660
- Functional Grade
- PE-Cyanine7
- PerCP-eFluor 710
- Request custom conjugation
Product Specific Information
Description:
The JES3-9D7 monoclonal antibody reacts with human interleukin-10 (IL-10).
Applications Reported:
JES3-9D7 has been reported for use in intracellular staining and flow cytometric analysis.
Applications Tested:
Tested by intracellular staining and flow cytometric analysis of human activated cells.
Recommended usage ≤ 0.25 µg per test (100 µL final volume).
Cell number may range from 10⁵–10⁸ cells/test.
Optimal titration is recommended for best performance.
Fluorescence Characteristics:
- Excitation: 488–561 nm
- Emission: 578 nm
- Compatible Lasers: Blue, Green, Yellow-Green
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
IL-10 encodes a cytokine primarily produced by monocytes, with additional production by lymphocytes.
It regulates immune responses and inflammation by down-regulating Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages.
IL-10 enhances B cell survival, proliferation, and antibody production, and can inhibit NF-kappa B activity.
It is involved in the JAK-STAT signaling pathway and is essential for intestinal immune regulation.
Mutations in IL10 are linked to increased susceptibility to HIV-1 infection and rheumatoid arthritis.
Associated diseases include Graft-Versus-Host Disease and HIV Type 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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