Thermo Fisher Scientific Phospho-TRPV1 (Ser502) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

This antibody detects endogenous levels of VR1 only when phosphorylated at Ser502.

Target Information

TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons.
TRPV1 is a non-selective cation channel related to the TRP family, including TRPC3 and TRPC6. It is permeable to calcium, magnesium, and monovalent cations such as sodium and potassium.
Structurally, TRPV1 contains six transmembrane domains, a P-loop membrane domain, and three ankyrin repeat domains. It is activated by noxious heat and may function as a transducer of painful thermal stimuli.
TRPV1 mediates proton influx and may contribute to intracellular acidosis in nociceptive neurons. Expression is primarily limited to sensory ganglia neurons.
Four transcript variants of TRPV1 differing in the 5′ UTR sequence have been described.
Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.