Thermo Fisher Scientific Phospho-Torc1 (Ser151) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Product Specifications

Product Specific Information

Antibody detects endogenous levels of Torc1/Crtc1 only when phosphorylated at Ser151.

Target Information

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator in the SIK/TORC signaling pathway, being active when dephosphorylated and acting independently of CREB1 Ser-133 phosphorylation. Enhances the interaction of CREB1 with TAF4 and regulates the expression of specific CREB-activated genes such as the steroidogenic gene StAR. Potent coactivator of PGC1α and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons. In concert with SIK1, regulates the light-induced entrainment of the circadian clock by coactivating the CREB-mediated transcription of PER1, which plays an important role in photic entrainment of the circadian rhythm. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.