Thermo Fisher Scientific NPC1 Recombinant Rabbit Monoclonal Antibody (JB87-33)
NPC1 단백질을 표적하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC/IF, Flow cytometry에 적합합니다. 인간 시료 반응성이 있으며, 고순도 Protein A 정제 및 안정적 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific NPC1 Recombinant Rabbit Monoclonal Antibody (JB87-33)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JB87-33 |
| Immunogen | Recombinant protein within Human Niemann Pick C1 (aa 1,160–1,278) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles, store in dark |
| Shipping Conditions | Wet ice |
| RRID | AB_2848602 |
Product Specific Information
Positive Controls: SiHa, A549, HepG2, PC-3M, Rat kidney tissue, Human kidney tissue, Mouse testis tissue, SH-SY-5Y.
Target Information
Mutations in the Niemann-Pick disease type C1 (NPC1) gene result in a fatal progressive neurodegenerative disorder characterized by abnormal sequestration of lipids including cholesterol and glycosphingolipids.
NPC1 protein resides in the limiting membrane of endosomes and lysosomes, mediating intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolyzed and released as free cholesterol.
NPC1, along with FTO, MC4R, and PTER, has recently been identified as a risk locus for early-onset and morbid adult obesity in European populations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: MA5-34694_NPC1_O15118-1_Rabbit.svg, MA5-34694_NPC1_O15118-1_Rabbit_PDP.jpeg)
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