Thermo Fisher Scientific PSMA1 Recombinant Rabbit Monoclonal Antibody (JB89-30)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Positive Control:
Rat testis tissue, human liver cancer tissue, human pancreas tissue, mouse cerebellum tissue, K562, PC-3M, mouse testis tissue lysate, mouse colon tissue lysate.

Target Information

Proteolytic degradation is critical to maintaining appropriate levels of short-lived and regulatory proteins involved in cellular metabolism, stress response, antigen presentation, receptor modulation, ion channels, cell cycle regulation, transcription, and signaling.
The ubiquitin-proteasome pathway deconstructs most proteins in the cytosol and nucleus of eukaryotic cells, while others are degraded via the vacuolar pathway (endosomes, lysosomes, endoplasmic reticulum).

The 26S proteasome is an ATP-dependent, multisubunit (~31 subunits), barrel-shaped molecular complex (~2.5 MDa). It consists of a 20S proteolytic core and one or two 19S regulatory subunits that recognize ubiquitinated proteins, unfold them, and translocate them into the 20S lumen.

Defects in the ubiquitin-proteasome pathway are linked to several genetic diseases, including cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.