Thermo Fisher Scientific HLA-G Monoclonal Antibody (MEM-G/9), Biotin
인간 HLA-G1 및 HLA-G5에 특이적인 Biotin 결합 단일클론 항체로, IHC, ICC/IF, Flow Cytometry, ELISA 등 다양한 응용에 적합. Mouse와 교차 반응하지 않으며, 4°C에서 보관. 연구용으로만 사용 가능.
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Thermo Fisher Scientific HLA-G Monoclonal Antibody (MEM-G/9), Biotin
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | 5–10 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 2–5 µg/mL | - |
| Flow Cytometry (Flow) | 1–5 µg/mL | View 1 publication |
| ELISA | Assay-dependent | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
| Affinity Purification (AP) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-G/9 |
| Immunogen | Recombinant human HLA-G refolded with beta-2 Microglobulin and peptide |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1076721 |
Additional Formats
Product Specific Information
This antibody reacts with an extracellular epitope on the native form of human HLA-G1 on the cell surface as well as with soluble HLA-G5 isoform in its beta2-microglobulin associated form. Reactivity with HLA-G3 has also been reported.
It does not cross-react with mouse.
Target Information
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane and expressed on fetal-derived placental cells.
The heavy chain is approximately 45 kDa and its gene contains 8 exons:
- Exon 1 encodes the leader peptide
- Exons 2 and 3 encode the α1 and α2 domains (peptide-binding)
- Exon 4 encodes the α3 domain
- Exon 5 encodes the transmembrane region
- Exon 6 encodes the cytoplasmic tail
HLA and MHC antibodies play a significant role in immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem mass spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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