Thermo Fisher Scientific CD31 Monoclonal Antibody (MEM-05), Biotin
CD31(PECAM-1)에 특이적인 Mouse Monoclonal Antibody로, Biotin으로 표지되어 있습니다. Flow Cytometry, IHC, WB 등 다양한 응용에 사용 가능하며, Human 시료에 반응합니다. 액상 형태로 제공되며 4°C 보관 권장.
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Thermo Fisher Scientific CD31 Monoclonal Antibody (MEM-05), Biotin
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 2–4 µg/mL |
| Immunoprecipitation (IP) | – |
| Miscellaneous PubMed (Misc) | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-05 |
| Immunogen | Leukocytes from a patient suffering from a LGL type leukaemia |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1072125 |
Additional Formats
Product Specific Information
This antibody reacts with an extracellular epitope of CD31 (PECAM-1), a 130–140 kDa type I transmembrane glycoprotein expressed on monocytes, platelets, granulocytes, endothelial cells, and stem cells of the myeloid lineage.
Target Information
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in the regulation of T cell and B cell signaling through immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Upon phosphorylation, these motifs serve as docking sites for protein-tyrosine phosphatases.
CD31 is expressed ubiquitously within the vascular compartment, mainly at junctions between adjacent cells. The N-terminal Ig-like domain mediates homophilic binding, crucial for cell-cell interactions.
This multifunctional molecule plays roles in:
- Modulation of integrin-mediated cell adhesion
- Transendothelial migration and angiogenesis
- Apoptosis and immune regulation
- Autoimmunity, macrophage phagocytosis, and thrombosis
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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