Thermo Fisher Scientific HLA-G Monoclonal Antibody (MEM-G/1), Biotin

Applications

Product Specifications

Additional Formats

• Unconjugated
• Request custom conjugation

Product Specific Information

This antibody reacts with an extracellular epitope of denaturated HLA-G heavy chain.
HLA-G belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and is expressed on the surface of trophoblast cells.

Target Information

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin).
The heavy chain is anchored in the membrane and is approximately 45 kDa. The gene contains 8 exons:

• Exon 1 encodes the leader peptide
• Exons 2 and 3 encode the alpha1 and alpha2 domains (peptide binding)
• Exon 4 encodes the alpha3 domain
• Exon 5 encodes the transmembrane region
• Exon 6 encodes the cytoplasmic tail

HLA-G is expressed on fetal-derived placental cells.
HLA and MHC antibodies are important in Immunopeptidomics, aiding in neoantigen identification and characterization using HPLC and tandem Mass Spectrometry.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.