Thermo Fisher Scientific RAB21 Monoclonal Antibody (OTI6F11), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, an additional desalting step is recommended (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

RAB21 is a member of the small GTP-binding protein family within the Ras superfamily, involved in intracellular vesicular trafficking.
In non-polarized Caco-2 cells, RAB21 shows ER-like localization, while in polarized cells it localizes to apical vesicles.
It associates with integrin subunits and plays a role in receptor entry into cells via RAB5/RAB21 endosomes.
The GTPase-activating protein p120RasGAP regulates cell motility by controlling the recycling of endocytosed integrins, competing with RAB21 for binding to overlapping sites on the alpha-tail of integrins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.