Thermo Fisher Scientific RAB21 Monoclonal Antibody (OTI6A9), TrueMAB
RAB21 단백질을 인식하는 Mouse monoclonal antibody로 Western blot, IHC, ICC에 적합합니다. HEK293T 세포에서 발현된 full-length human RAB21 단백질로 면역생성되었습니다. 동결건조 형태로 제공되며, PBS buffer에 8% trehalose를 포함합니다. 연구용 전용 제품입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:4,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6A9 |
| Immunogen | Full length human recombinant protein of human RAB21 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, an additional desalting step is recommended (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
RAB21 is a member of the small GTP-binding protein gene subfamily within the Ras superfamily, playing a key role in intracellular vesicular trafficking.
In non-polarized Caco-2 cells, RAB21 shows ER-like localization, while in polarized cells, it localizes to apical vesicles.
RAB21 associates with integrin subunits and is important for receptor entry via RAB5/RAB21 endosomes.
The GTPase-activating protein p120RasGAP regulates cell motility by controlling integrin recycling to the plasma membrane through competition with RAB21 for binding sites on the alpha-tail of endocytosed integrin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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